Antimycobacterial flavones from Haplopappus sonorensis |
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| Authors: | Murillo J I Encarnación-Dimayuga R Malmstrøm J Christophersen C Franzblau S G |
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| Institution: | Universidad Autónoma de Baja California Sur, Departamento de Agronoma, A P 19-B, La Paz, BCS 23080, Mexico. |
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| Abstract: | Crude extracts of Haplopappus sonorensis (A. Gray) S.F. Blake (Asteraceae), showed activity against Mycobacterium tuberculosis H(37)Rv. By assay-guided fractionation, 5-hydroxy-3,7,4'-trimethoxyflavone (1). 5,7-dihydroxy-3,4'-dimethoxyflavone (2). and 5,4'-dihydroxy-3,7-dimethoxyflavone (3). were identified as the antimycobacterial principles. Compound 2 was the most active compound. |
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