人工感染弓形虫兔主要脏器病理形态学观察

将人工感染弓形虫兔于濒死期(3～46d不等)扑杀,取其心、肝、脾、肺和肾五种脏器组织,作了病理形态学观察。主要结果如下:肝、心、脾组织中有周边无炎性反应的凝固性坏死;肝组织中还有网状细胞增生形成的结节;肺脏表现为肺泡隔炎等,这些特征性病变与其他动物弓形虫病变基本相同。同时观察到在肝窦状隙、小叶间动、静脉、肺泡壁毛细血管、肺支气管动脉、心肌纤维间毛细血管和脾静脉窦内均有血栓形成,同时伴?坏死性血栓性血管炎;各脏器的动脉管壁呈现不同程度的玻璃样变,以及由血栓形成所致其周围组织的病变。另外,应用PAS、PTAH、Weigert-Gram等染色方法显示组织切片中的弓形虫,比H.E染色更易于观察。

PATHOMORPHOLOGICAL OBSERVATION ON THE MAJOR ORGANS OF RABBITS ARTIFICIALLY INFECTED WITH TOXOPLASMAE

The rabbits artificially infected with toxoplasmae were sacrificed in dif-ferent stages of infection and underwent necropsy. Tissue specimens form the heart,liver, spleen, lungs and kidneys were observed. Characteristic changes were seen inthe liver, heart and spleen, there were foci of coagulation necrosis and hyperplast-ic foci of reticular cells involving any part of the hepatic lobules. The lungs hadrather stri?ing changes particularly in the alveolar valls(so -called septa-al eolitis ).These are same as pathological findings of toxoplasmosis in other animals. In addi-tion, thrombi formed in the hepatic sinusoids, arteries and veins of the potal area,capillaries of the alveolar walls and arteries of bronchiole, capillaries betweenmyocardial fibres, and spleenic venous sinus. The vessels accompanied with necroticthrombotic angiitis. Hyalinization was found in the walls of the vessels of themajor organs.