Dioscorea opposita reverses dexamethasone induced insulin resistance |
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| Authors: | Gao Xiaoping Li Bogang Jiang Hanwen Liu Fenglin Xu Dayong Liu Zhongrong |
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| Affiliation: | Institute of Materia Medica, Di-Ao Pharmaceutical Group, Chengdu 610041, China. gxplww2003@yahoo.com.cn |
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| Abstract: | The effects of Dioscorea opposita (huai shan yao, HSY) on dexamethasone-induced insulin resistance were investigated in vitro and in vivo. D. opposita extract reduced significantly the blood insulin and glucose levels in dexamethasone-induced diabetic rats. In vitro, HSY significantly enhanced insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Moreover, HSY increase the mRNA expression of GLUT4 glucose transporter in 3T3-L1 adipocytes. These data suggest that D. opposita has insulin sensitivity that is associated with the regulation of GLUT4 expression. |
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| Keywords: | Dioscorea opposita Insulin resistance Dexamethasone 3T3-L1 adipocytes GLUT4 |
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