| 芳甲酰氨基环丙酸的合成及其生物活性 |
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| 引用本文： | 周繁,冉兆晋,谭伟明,李召虎,段留生.芳甲酰氨基环丙酸的合成及其生物活性[J].农药学学报,2013,15(5):490-495. |
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| 作者姓名： | 周繁 冉兆晋 谭伟明 李召虎 段留生 |
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| 作者单位： | 1.中国农业大学 农学与生物技术学院, 植物生长调节剂教育部工程研究中心, 北京 100193 |
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| 基金项目： | 国家高技术研究发展计划(863计划)项目(2011AA10A206). |
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| 摘 要： | 以与脱落酸具有相同受体的化合物pyrabactin为先导,用1-氨基环丙酸替代2-氨甲基吡啶,设计合成了17个具有脱落酸功能的类似物(芳甲酰氨基环丙酸),其中13个为未经文献报道的新化合物。其结构均经过核磁共振氢谱、红外光谱和高分辨质谱(HRMS)确证。初步生物活性测试结果表明,大部分目标化合物表现出一定的延缓种子萌发活性,其中化合物 B4、B8和B11在5000μmol/L时的活性优于脱落酸。
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| 关 键 词： | 脱落酸类似物 pyrabactin 合成 种子萌发 生物活性 |
| 收稿时间： | 2013/8/28 0:00:00 |
| 修稿时间： | 2013/9/18 0:00:00 |
Synthesis and biological activity of arylamido-cyclopropanecarboxylic acid |
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| ZHOU Fan,RAN Zhaojin,TAN Weiming,LI Zhaohu and DUAN Liusheng.Synthesis and biological activity of arylamido-cyclopropanecarboxylic acid[J].Chinese Journal of Pesticide Science,2013,15(5):490-495. |
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| Authors: | ZHOU Fan RAN Zhaojin TAN Weiming LI Zhaohu and DUAN Liusheng |
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| Institution: | 1.College of Agronomy and Biotechnology, China Agricultural University & Engineering Research Center of Plant Growth Regulator, Ministry of Education, Beijing 100193, China |
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| Abstract: | Using pyrabactin which has the same receptor as abscisic acid(ABA) as the lead compound,seventeen arylamido-cyclopropanecarboxylic acid compounds were designed and synthesized by replaced 2-Picolylamine with 1-aminocyclopropanecarboxylic acid.Among them thirteen novel title compounds have not been reported in the literatures.Their structures were confirmed by 1H NMR,IR spectra and HRMS.The preliminary bioassay revealed that the most compounds showed the bioactivity of delaying germination.In particular,the compounds B4, B8 and B11 showed the better bioactivity than ABA at the concentration of 5 000μmol/L in wheat. |
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| Keywords: | abscisic acid analogue pyrabactin synthesis germination bioactivity |
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