| 大白芸豆植物凝集素毒性研究 |
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| 引用本文： | 王昌梅,张丽芬,杨明洁,张田,王敏康.大白芸豆植物凝集素毒性研究[J].安徽农业科学,2009,37(28):13639-13640. |
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| 作者姓名： | 王昌梅 张丽芬 杨明洁 张田 王敏康 |
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| 作者单位： | 云南师范大学生命科学学院,云南昆明,650092 |
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| 基金项目： | 国家自然科学基金资助，云南省中青年学术技术带头人后备人才培养计划，云南省教育厅科研基金资助 |
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| 摘 要： | 目的]评价植物凝集素的急性毒性反应，为临床应用提供依据。方法]小鼠腹腔单次注射不同剂量植物凝集素，观察其急性毒性状况和死亡情况.结果]腹腔注射植物凝集素的结果是昆明小白鼠腹腔注射的肋。是140．24mg／kg，95％置信区间为125．19～178．91mg／kg.结论]云南丽江大白芸豆植物凝集素属于中等到低等毒性，使用时必须遵照安全剂量范围。
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| 关 键 词： | LD50 植物凝集素 急性毒性试验 昆明小白鼠 |
Toxicity Study on Phytohemagglutinin from White kidney Bean |
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| WANG Chang-mei et al.Toxicity Study on Phytohemagglutinin from White kidney Bean[J].Journal of Anhui Agricultural Sciences,2009,37(28):13639-13640. |
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| Authors: | WANG Chang-mei |
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| Institution: | WANG Chang-mei et al(School of Life Science,Yunnan Normal University,Kunming,Yunnan 650092) |
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| Abstract: | Objective]The research aimed to evaluate the acute toxicity reaction of phytohemagglutinin(PHA) and provide a basis for clinical application.Method]Kunming mice were injected through abdominal cavity one time with different dosage of PHA,observing their acute toxicity status and mortality situation.Result]The results showed that the LD_(50) was 140.24 mg/kg,95%confidence interval was 125.19 - 178.91 mg/kg.Conclusion]Because the PHA of white kidney bean from Yunnan Lijian was middle to low toxicity,it mu... |
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| Keywords: | LD50 |
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