FeLV-FAIDS-induced immunodeficiency syndrome in cats |
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| Authors: | J I Mullins E A Hoover J Overbaugh S L Quackenbush P R Donahue M L Poss |
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| Affiliation: | Department of Cancer Biology, Harvard University School of Public Health, Boston, MA 02115. |
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| Abstract: | Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV). |
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