Amplification of the cyclin A gene in canine and feline mammary tumors |
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Authors: | Murakami Y Tateyama S Rungsipipat A Uchida K Yamaguchi R |
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Institution: | Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Japan. |
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Abstract: | DNAs from 33 canine mammary tumors and 8 feline mammary carcinomas were examined by Southern blot analysis to clarify genomic abnormalities of the cyclin A gene. Amplification of cyclin A was detected in 27.3% (9/33) of canine mammary tumors and 87.5% (7/8) of feline mammary carcinomas. It was suggested that amplification of cyclin A do not correlate directly with the tumorigenesis of canine mammary tumors, because there was no significant difference of incidence of cyclin A amplification between the benign and malignant tumors. In feline mammary carcinomas, the high frequency of cyclin A amplification raised the possibility that the amplification lead to the protein overexpression and play an important role in the tumorigenesis. |
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