Liver disease in young rabbits infected by calicivirus through nasal and oral routes |
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| Affiliation: | 1. Landcare Research, PO Box 1930, 9054 Dunedin, New Zealand;2. Instituto de Investigación en Recursos Cinegéticos (IREC-CSIC-UCLM-JCCM), Ronda de Toledo, s/n, 13071 Ciudad Real, Spain;3. Departamento de Zoología, Campus de Rabanales, Universidad de Córdoba, 14071 Córdoba, Spain;4. Ethology and Biodiversity Conservation Department, Doñana Biological Station-CSIC, Américo Vespucio s/n, 41092 Seville, Spain;5. CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBio Laboratório Associado, Campus Agrário de Vairão, Universidade do Porto, 4485-661 Vairão, Portugal;6. Instituto de Estudios Sociales Avanzados (IESA-CSIC), Campo Santo de los Mártires, 14004 Córdoba, Spain;1. Department of Plant and Wildlife Sciences, Brigham Young University, Provo, UT 84602, USA;2. Monte L. Bean Life Sciences Museum, Brigham Young University, Provo, UT 84602, USA;3. Department of Biology, Brigham Young University-Idaho, Rexburg, ID 83460, USA;4. Southwest Alaska Network, National Park Service, Anchorage, AK 99501, USA;5. Department of Natural Resource Management, South Dakota State University, Brookings, SD 57006, USA;1. Department of Microbiology, Faculty of Biology, Adam Mickiewicz University in Poznań, Umultowska 89, 61-614 Poznań, Poland;2. Department of Animal Taxonomy and Ecology, Faculty of Biology, Adam Mickiewicz University in Poznań, Umultowska 89, 61-614 Poznań, Poland;1. Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China;2. Key Lab of Reproduction Regulation of NPFPC, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai 200032, China;3. Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830001, China;4. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China;1. Departamento de Patologia e Clínica Veterinária, Faculdade de Veterinária, Universidade Federal Fluminense, Rua Vital Brasil Filho, 64, 24320-340, Niteroi, RJ, Brazil;2. Embrapa Goats and Sheep, Rodovia MG 133, km 42, CEP 36155-000, Coronel Pacheco, MG, Brazil;1. Department of Pathology, University Medical Center Utrecht, The Netherlands;2. Department of Gastroenterology & Hepatology, University Medical Center Utrecht, The Netherlands;3. Department of Cardio Thoracic Surgery, University Medical Center Utrecht, The Netherlands;4. Department of Cardiology, University Medical Center Utrecht, The Netherlands |
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| Abstract: | Calicivirus infection causes rabbit haemorrhagic disease (RHD) that kills more than 90% of adult animals, whereas young rabbits are naturally resistant to this viral disease. It has been proposed that the different response of adult and young rabbits to calicivirus infection is due to absence of viral receptors in respiratory and digestive systems of young animals. We have searched for liver disease in 4-week-old rabbits inoculated with a calicivirus suspension by intranasal and oral routes. These young rabbits showed cell damage and mononuclear infiltration of the liver. The hepatic lesions were associated with mild to moderate increase in circulating transaminases. We conclude that the previously reported reduction of viral receptors in the epithelium of respiratory and digestive systems of young rabbits does not inhibit calicivirus from inducing liver disease in these hosts. |
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