埃索美拉唑与奥美拉唑三联疗法治疗十二指肠球部溃疡的愈合率及Hp根除率比较

目的:观察埃索美拉唑、奥美拉唑三联疗法两周治疗十二指肠球部溃疡的愈合率及Hp根除率比较。方法:幽门螺杆菌(Hp)阳性的十二肠球部溃疡A1期患者113例随机分为两组:埃索美拉唑组57例,奥美拉唑组56例。两组均先给予三联治疗(埃索美拉唑20mg或奥美拉唑20mg 阿莫西林lg 克拉霉素500mg,2次/d),连续7d,然后分别单独给予埃索美拉唑20mg(1次/d)或奥美拉唑20mg(1次/d)7d,停药后4～6周复查内镜并检测Hp,观察溃疡的愈合情况及Hp根除率。结果:埃索美拉唑组d1和d2腹痛缓解率分别为35.1%和61.4%,高于奥美拉唑组的16.1%和37.5%(P<0.05)。埃索美拉唑组和奥美拉唑组2周溃疡愈合率分别为93.0%和80.4%,差异有统计学意义(P<0.05)。Hp根除率分别为89.5%和80.4%,差异无统计学意义(P>0.05)。结论:埃索美拉唑三联疗法2周治疗十二指肠球部溃疡在缓解腹痛及溃疡愈合率均优于奥美拉唑。

Comparison of Esomeprazole and Omeprazole Based Triple Therapy Regimens for Duodenal Ulcer with Helicobacter Pylori Infection

Objective:To investigate the effect of esomeprazole-and omeprazole-based triple therapy regimens in the treatment of duodenal ulcer with Helicobacter pylori (Hp)infection. Methods:113 patients with duodenal ulcer(A1) and Hp infection were randomly divided into 2 groups. Esomeprazole group(57cases) treated with esomeprazole(20mg),amoxicillin(1000mg)and clarithromycin(500mg)twice daily for one week,then esomeprazole 20mg once daily for one week.Omeprazole group(56cases) treated with omeprazole(20mg),amoxicillin(1000mg)and clarithromycin(500mg)twice daily for one week,then Omeprazole 20mg once daily for one week. After 4 to 6 weeks,the second endoscopic and Hp examinations were made to evaluate the ulcer healing rate and Hp eradication rate. Results:On the first and second days of medication,the abdominal pain relief rates were 35.1% and 61.4% respectively in esomeprazole group,significantly higher than those in omeprazole group(16.1%and 37.5%,P<0.05). Ulcer healing rate were 93.0% in esomeprazole group and 80.4% in omeprazole group(P<0.05). Hp eradication rate were 89.5% in esomeprazole group and 80.4% in omeprazole group,showing no significant diferences between the two groups (P>0.05). Conclusion:The Esomeprazole has more advantages than the Omeprazole in healing duodenal ulcer and relieving pain.