Two different types of malignant fibrous histiocytomas from pet dogs |
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Authors: | Sun Hee Do Il-Hwa Hong Jin-Kyu Park Ae-Ri Ji Tae-Hwan Kim Dong-Mi Kwak Kyu-Shik Jeong |
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Institution: | 1Department of Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.;2Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea. |
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Abstract: | We describe 2 cases of malignant fibrous histiocytomas (MFHs) that spontaneously developed in young pet dogs. To classify these tumors, we applied a panel of antibodies (vimentin, desmin, α-SMA, and ED1) and Azan staining for collagen. The MFHs were most consistent with osteoclast-like giant and inflammatory cell types. The first case had positive staining for ED1 and vimentin, and given the osteoclast-like giant cells, calcification sites accompanying peripheral giant cell infiltrates. The latter case, the inflammatory cell type, exhibited a storiform-pleomorphic variant of neoplastic cells, including an ossifying matrix. MFHs are among the most highly aggressive tumors occurring in soft tissue sarcomas in elderly dogs; however, MFHs have been poorly studied from a diagnostic point of view. Herein, we describe the histologic and immunohistologic features of MFHs in detail, thus classifying the subtypes of these tumors. |
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Keywords: | dog inflammatory malignant fibrous histiocytoma osteoclast-like giant cell |
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