7-氯-2,5-二氢茚并[1,2-e][1,3,4]噁二嗪-4a-(3H) -羧酸甲酯的合成研究 |
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引用本文: | 贾鹏飞,王娟,刘占荣,周二鹏. 7-氯-2,5-二氢茚并[1,2-e][1,3,4]噁二嗪-4a-(3H) -羧酸甲酯的合成研究[J]. 安徽农业科学, 2012, 40(17): 9336-9337 |
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作者姓名: | 贾鹏飞 王娟 刘占荣 周二鹏 |
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作者单位: | 石家庄学院化工学院,河北石家庄,050035;石家庄学院化工学院,河北石家庄,050035;石家庄学院化工学院,河北石家庄,050035;石家庄学院化工学院,河北石家庄,050035 |
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基金项目: | 石家庄市科学技术研究与发展指导计划项目(101071401);石家庄学院教学改革研究项目(2009004) |
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摘 要: | [目的]探讨合成7-氯-2,5-二氢茚并[1,2-e][1,3,4]噁二嗪-4a-(3H)-羧酸甲酯的新方法。[方法]以5-氯-1-氧-2,3-二氢茚-2-羧酸甲酯为起始原料,先后经过不对称氧化、肟化、环合、取代反应得到目标化合物。[结果]目标产物及中间体的结构已通过质谱、1H NMR进行表征。[结论]该合成方法具有原材料易得、收率高、成本低等优点。
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关 键 词: | 7-氯-2 5-二氢茚并[1 2-e][1 3 4]噁二嗪-4a-(3H)-羧酸甲酯 茚虫威 合成 |
Synthesis of Methyl 7-chlor-2,5-dihydroindenooxadiazine-4a-(3H)-carboxylate |
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Affiliation: | JIA Peng-fei et al(School of Chemical Engineering,Shijiazhuang University,Shijiazhuang,Hebei 050035) |
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Abstract: | [Objective]To investigate a novel synthesis method of methyl 7-chlor-2,5-dihydroindenooxadiazine-4a-(3H)-carboxylate.[Method]Methyl 5-chlor-1-oxo-2,3-dihydroindeno-2-carboxylate was used as the starting material to synthesize target compound through asymmetric oxidation,oximation,cyclization and substitution reaction.[Result] The intermediate and title compound were identified with 1H NMR and MS.[Conclusion] The synthesis method has the advantages of readily available raw material,higher yield and lower cost. |
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Keywords: | Methyl 7-chlor-2,5-dihydroindenooxadiazine-4a-(3H)-carboxylate Indoxacarb Synthesis |
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