Jaagsiekte sheep retrovirus is present at high concentration in lung fluid produced by ovine pulmonary adenocarcinoma-affected sheep and can survive for several weeks at ambient temperatures |
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Authors: | Christina Cousens Leenadevi Thonur Joanne Crawford David J Griffiths |
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Institution: | a Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 0PZ, UK b Biomathematics and Statistics Scotland, Kings Buildings, Edinburgh EH9 3JZ, UK |
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Abstract: | Jaagsiekte sheep retrovirus (JSRV) causes a fatal lung cancer of sheep known as ovine pulmonary adenocarcinoma (OPA). OPA is a significant disease in many sheep-rearing countries and there is no effective method of control. A unique feature of OPA is the overproduction of fluid in the lung of affected animals. This lung fluid contains JSRV and provides a means of transmission through the inhalation of virus. In this study we demonstrated that lung fluid from different OPA cases contained between 107 and 1010 copies of JSRV RNA per ml. Examination of JSRV RNA survival under conditions that mimic natural conditions suggested that intact JSRV virions may persist for several weeks in the environment. These are the first quantitative data on JSRV in lung fluid and provide valuable information for implementing appropriate biosecurity measures to control the spread of JSRV in the field. |
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Keywords: | Jaagsiekte OPA Retrovirus Sheep Virus survival |
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