Choline administration: modification of the central actions of atropine |
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| Authors: | Wecker L Dettbarn W D Schmidt D E |
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| Affiliation: | Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. |
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| Abstract: | The anticholinergic agent atropine decreases acetylcholine concentrations and increases high-affinity choline uptake in cortical and hippocampal regions of rat brain. Administration of choline 1 hour before atropine prevents both of these atropine-induced alterations. These findings suggest that alterations in acetylcholine precursor availability may modify the effects of centrally active anticholinergic agents. |
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