An unmatched case controlled study of clinicopathologic abnormalities in dogs with Bartonella infection |
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| Institution: | 1. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC;2. Carolina Center for Health Informatics, Department of Emergency Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC;3. Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC;4. School of Nursing, University of North Carolina, Chapel Hill, NC;5. Department of Pulmonary Diseases and Critical Care Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC;6. Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC;1. Department of Medical and Molecular Genetics, Division of Clinical and Biochemical Genetics, Indiana University School of Medicine, Indianapolis, IN, United States;2. Hyperion Therapeutics, Inc., Brisbane, CA, United States |
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| Abstract: | We compared clinicopathologic findings in dogs with Bartonella infection to Bartonella spp. negative dogs suspected of a vector-borne disease. Cases (n = 47) and controls (n = 93) were selected on the basis of positive or negative enrichment culture PCR results, respectively. Signalment, clinicopathologic findings and treatments were extracted from medical records. DNA sequencing identified Bartonella henselae (n = 28, 59.6%), Bartonella vinsonii subsp. berkhoffii (n = 20, 42.6%), Bartonella koehlerae (n = 3, 6.4%), Bartonella volans-like (n = 3, 6.4%) and Bartonella bovis (n = 1, 2.1%). There were no significant differences in age, breed, size, sex or neuter status between cases and controls. Dogs infected with Bartonella sp. often had a history of weight loss OR = 2.82; 95% CI: 1.08–7.56] and were hypoglobulinemic OR = 4.26; 95% CI: 1.31–14.41]. With the exception of weight loss and hypoglobulinemia, clinicopathologic abnormalities in Bartonella-infected dogs in this study were similar to dogs suspected of other vector-borne infections. |
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| Keywords: | Dogs BAPGM Enrichment PCR Hypoglobulinemia |
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