Efficacy and safety of lomefloxacin on bacterial extraocular disease in the
horse |
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Authors: | Shuhei HIDAKA Mitsutoshi KOBAYASHI Kunihide ANDO Yoshikazu FUJII |
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Institution: | 1)Horse Clinic, Bloodhorse Training Center (BTC), 141 Nishisha, Urakawa-cho, Urakawa-gun, Hokkaido 057–0171, Japan;2)Secretariat, Tokyo, BTC, 1–1 Hiyoshi-cho, Fuchu-shi, Tokyo 183–0024, Japan |
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Abstract: | Lomefloxacin is a broad-spectrum fluoroquinolone antibiotic used for the treatment of
bacterial extraocular disease. This study investigated the efficacy and safety of
lomefloxacin eye drops for bacterial extraocular disease in horses. Lomefloxacin
ophthalmic solution (0.3%) was instilled three times daily for 2–5 days in 65 horses
diagnosed with bacterial extraocular disease based on clinical findings. Clinical
observations and bacteriological examinations were performed at the start of treatment, 2
and 5 days after the start of treatment, and at the discontinuation or termination of
treatment. Of the 65 horses, 64 were positive for bacteria, and 22 bacterial genera and 47
bacterial species were identified. The efficacy of lomefloxacin was evaluated in 63
horses; one horse with a negative culture and another with suspected bacterial
contamination were excluded. Lomefloxacin was considered to be clinically effective in 54
horses. The major bacterial species identified were Staphylococcus
aureus, Streptococcus equi subsp. zooepidemicus,
Acinetobacter lwoffii, Staphylococcus xylosus,
Staphylococcus vitulinus, Enterobacter agglomerans,
Flavimonas oryzihabitans and Staphylococcus sciuri,
with a cumulative disappearance rate of 80% or more at the termination of instillation.
Excluding one horse that did not undergo a bacteriological examination, the remaining 62
horses were assessed for bacteriological outcome. Full or partial bacterial clearance was
detected in 95% or more of the 62 horses. One of the 65 horses reported adverse events
that had no causal relation with the eye drops. Our results showed that lomefloxacin is
safe and effective for the treatment of bacterial extraocular disease in horses. |
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Keywords: | bacterial culture bacterial extraocular disease clinical study equine lomefloxacin |
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