In vivo long-term effects of retinoic acid exposure in utero on induced hyperplastic epidermal foci in murine skin |
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Authors: | García-Fernández Rosa A Pérez-Martínez Claudia Espinosa-Alvarez Javier García-Iglesias Maria J |
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Affiliation: | Histology and Pathological Anatomy Section, Department of Animal Medicine and Surgery, Faculty of Veterinary Science, University of Madrid (UCM), Madrid, Spain. |
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Abstract: | Adult Naval Medical Research Institute (NMRI) mice, after prenatal exposure to retinoic acid (RA), were treated with a standard two-stage skin carcinogenesis regime to characterize hyperplastic epidermal foci that precede the appearance of cutaneous papillomas, and to investigate the in vivo long-term action of RA on adult mouse skin treated with DMBA (7,12 dimethyl benz[a]anthracene) and TPA (12-O-tetradecanoylphorbol 13-acetate). The results demonstrate that RA administered to pregnant mice had a long-term inhibitory action on the cell differentiation and development of hyperplastic lesions occurring prior to cancer on the adult skin of their offspring as well as a stimulatory effect on cell proliferation of these hyperplastic lesions. |
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