Immunohistochemical and ultrastructural analyses of cytoplasmic blood plasma inclusions of rat hepatocytes |
| |
Authors: | Tochitani Tomoaki Toyosawa Kaoru Matsumoto Izumi Kouchi Mami Michimae Yoshiko Koujitani Takatoshi Funabashi Hitoshi Seki Takaki |
| |
Affiliation: | Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan. |
| |
Abstract: | In the present study, we investigated the histological, immunohistochemical and ultrastructural characteristics of cytoplasmic blood plasma inclusions that spontaneously occurred in a rat liver. Histologically, a number of cytoplasmic inclusions were observed in the liver of an 8-week-old female SD rat. These inclusions were strongly positive for PAS staining and resistant to diastase digestion. Immunohistochemical analyses revealed that these inclusions were positive for albumin and IgG; however, most of them were negative for LAMP-1 and LAMP-2. Ultrastructurally, the inclusions were surrounded by limiting membranes and composed of moderately electron dense, homogenous materials. These characteristics described here represent valuable information for pathological examination in toxicity studies. |
| |
Keywords: | rats liver spontaneous lesions blood plasma inclusions |
本文献已被 PubMed 等数据库收录! |
|