| 从内毒素激活效应细胞的分子机制谈抗内毒素药物的研究进展 |
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| 引用本文： | 侯小强,张乃生. 从内毒素激活效应细胞的分子机制谈抗内毒素药物的研究进展[J]. 吉林畜牧兽医, 2002, 0(1): 10-12 |
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| 作者姓名： | 侯小强 张乃生 |
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| 作者单位： | 解放军军需大学动物科技系,吉林,长春,130062;解放军军需大学动物科技系,吉林,长春,130062 |
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| 摘 要： | 脂多糖(Lps)是一类具有高度活性的大分子物质,可依赖LBP/CD14系统作用于细胞,特别是单核细胞、巨噬细胞和中性粒细胞(PMNS)等通过一系列胞内信号传导系统诱导细胞产生多种生物活性分子,如:TNF-α,白介素,前列腺素等,在革兰氏阴性菌感染的发病机制中扮演着十分重要的角色,其可激活损伤血管内皮细胞,引起机体产生局部炎症反应和弥散性血管内凝血(DIC)等病理反应,引起发热,呼吸窘迫综合症,心肺功能严重损害及多器官功能衰竭(MOF),甚至引发致死性休克,因此全面了解内毒素的作用机制,研究有效的内毒素拮抗剂,对预防和治疗内毒素(ET)性疾病有重要意义。
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| 关 键 词： | 抗内毒素药物 效应细胞 进展 |
From Molecul Mechanism of Endotoxin activating Effector Cell to discuss investigational Progress of Anti-endotoxin drug |
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| Hou Xiaoqiang,Zhang Naisheng. From Molecul Mechanism of Endotoxin activating Effector Cell to discuss investigational Progress of Anti-endotoxin drug[J]. Jilin Animal Science and Veterinary Medicine, 2002, 0(1): 10-12 |
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| Authors: | Hou Xiaoqiang Zhang Naisheng |
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| Abstract: | Depending on LBP/CD14 systems Lps activates a series of signal-transdcing systems in cells and carses body to bring about pathological effect, for example inflammatory reaction, Dic and so on. From molecul mechanism of endotoxin activating effector cell to research anti-endotoxin drug is very effective. This article gives a summary about signal transduction in cells induced by endotoxin and effective reason of anti-en-dotoxin drug. |
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| Keywords: | anti-endotoxin drug effector cell progress |
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