Development of FIV-specific cytolytic T-lymphocyte responses in cats upon immunisation with FIV vaccines |
| |
Institution: | 1. Institute of Parasitology, Department of Pathobiology, University of Veterinary Medicine, A-1210 Vienna, Austria;2. Institute of Microbiology, Department of Pathobiology, University of Veterinary Medicine, A-1210 Vienna, Austria |
| |
Abstract: | Vaccine protection has been achieved in cats against experimental infection with feline immunodeficiency virus (FIV). Such protection has been attributed to FIV-specific humoral immunity, as well as cellular immunity of unknown mechanism(s). Since cell-mediated immunity plays a crucial role in the clearance of viral infections, this study evaluated the role of FIV-specific CTL in vaccine prophylaxis. Cats were immunised with inactivated FIV vaccines, reported to have >90% vaccine efficacy. Significant levels of specific CTL activity were detected following the third immunisation. CTL activity persisted for several months and could be enhanced through a booster immunisation. The levels of CTL activity were comparable to those induced by a recombinant canarypoxvirus based FIV vaccine. These results suggest a possible role for CTL-mediated immunity in vaccine protection against FIV infection in cats. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|