Prolonged persistence of Listeria monocytogenes after intragastric infection in corticosteroid-treated mice |
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Affiliation: | 1. Nestlé Institute of Food Safety & Analytical Sciences, Nestlé Research, Nestec Ltd., Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland;2. Mérieux NutriSciences, Silliker Food Science Center, Crete, IL 60417, USA;1. Laboratory of Microbiology and Technology of Marine Products (MICROTEC), Instituto de Investigaciones Marinas (IIM-CSIC), Eduardo Cabello, 6, 36208 Vigo, (Pontevedra), Spain;2. Department of Food and Drug, Università di Parma, Strada del Taglio, 10, 43126 Parma, (PR), Italy |
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Abstract: | In an attempt to obtain a model more closely resembling natural listeriosis, we studied the course of infection in mice inoculated by the intragastric route with Listeria monocytogenes. Corticosteroid-treated, and untreated mice both developed subclinical infection without mortality, but faecal shedding and peristence of bacteria in the liver and spleen of corticosteroid-treated mice were significantly more protracted than in untreated mice. Untreated mice cleared the bacteria from their livers and spleens by day 5 postinfection (PI), whereas treated mice did not clear the organisms until 8–9 days PI. In untreated mice faecal shedding lasted 5 days PI, whereas in treated mice the organisms were recovered at significantly higher levels until day 9 PI. The only intestinal lesions observed were mild pyogranulomatous changes in the dome area of some Peyer's patches in treated mice. |
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