Effects of α2-adrenergic drugs on blood platelets in sheep |
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Authors: | L Papazoglou D Raptopoulos M Kritsepi A Galatos |
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Institution: | Department of Clinical Studies, Veterinary School, University of Thessaloniki, Greece |
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Abstract: | Xylazine (0.2 mg/kg, iv) alone or preceded by atipame-zole (0.125 μg/kg, iv) or by aspirin (10 μg/kg, iv) was administered to 18 sheep. Medetomidine (60 μg/kg, iv) was also administered to 12 sheep. Xylazine, but not medetomidine, significantly reduced the number of platelets. Both atipamezole and aspirin prevented this reduction. It was concluded that α2-agonists would seem to produce platelet aggregation that may contribute to the development of the respiratory changes that follow the administration of α2-agonists in sheep, but probably not always to a degree that could result in a significant decrease in the number of circulating platelets. |
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