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The Effects of Hypertonic Saline in Healthy and Diseased Animals |
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| Authors: | Cambier C. Ratz V. Rollin F. Frans A. Clerbaux T. Gustin P. |
| Affiliation: | (1) Department of Pharmacology and Toxicology, University of Liège, B41, Sart Tilman, B-4000 Liège, Belgium;(2) Department of Pharmacology and Toxicology, University of Veterinary Medicine, 1400 Budapest, 1078 Istvan Utca 2, Hungary;(3) Department of Large Animals Internal Medicine, Faculty of Veterinary Medicine, University of Liège, B41, Sart Tilman, B-4000 Liège, Belgium;(4) Department of Internal Medicine, Division of Pneumology and Cardiology, Cliniques Universitaires Saint-Luc, UCL, B-1200 Brussels, Belgium |
| Abstract: | In this review, the pharmacological effects of administering hypertonic solutions to both healthy animals and during experimentally induced diseases are considered with a view to understanding the mechanisms behind the possible clinical efficacy of such treatment. The review focuses successively on haemorrhagic shock, endotoxic shock and hypokalaemic metabolic alkalosis. How hypertonic saline solutions affect oxygen transport by haemoglobin is also considered. |
| Keywords: | alkalosis endotoxin haemorrhage hypertonic saline hypochloraemia shock |
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