Endotoxins and endocrine system |
| |
| Institution: | 1. Chair of Department of Dermatology and Venereology, University of Rome “G. Marconi,” Rome, Italy;2. Division of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Italy;3. Department of Dermatology and Venereology, Second Faculty of Medicine, Charles University in Prague and Bulovka University Hospital, Prague, Czech Republic;1. Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, United States;2. Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, United States;3. Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, United States |
| |
| Abstract: | There is good evidence for the interaction of neuroendocrine and immune systems. Endotoxin (LPS)-induced mediators (e.g., cytokines, prostaglandins etc) set on endocrine organs (e.g., the hypothalamo-pituitry-adrenal axis; thyroid glands etc). Endotoxin-treated, intestinal ischemic, or irradiated rats show decreased T4 levels of blood. These animals cannot respond to TSH because the TSH-receptors of follicular membranes are disturbed by LPS in the thyroid glands. Radiodetoxified endotoxin is an effective immunstimulator and does not disturb the follicular membrane of thyroid gland. Thus, the T4 production remains normal. The bile acids—as the end-product of cholesterol metabolism—play an important role in the physiological defense of macroorganisms against endotoxin and other lipid-like agents (Physico-chemical defense) and in the regulation of endocrine system, including the reproduction. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
