Pituitary function in the acute phase response in domestic farm animals: cytokines,prostaglandins, and secretion of ACTH |
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| Affiliation: | 1. Department of Animal Sciences and Industry, Kansas State University, Manhattan, KS 66506-0201 USA;1. University of Florida, Agricultural Education and Communication, 121D Bryant Hall, P.O. Box 112060, Gainesville, FL 32611, United States;2. University of Florida, Department of Family, Youth and Community Sciences, 3025 McCarty Hall, Gainesville, FL 32611, United States;1. Department of Pediatric Endocrinology, New York Presbyterian Hospital, Weill Cornell Medical College, 505 East 70 Street, New York, NY 10021, USA;2. Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;1. Department of Surgery, Michigan Medicine, Ann Arbor, MI;2. University of Michigan Medical School, Ann Arbor, MI;3. Section of Transplant Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI;4. Department of Anesthesia, University of Michigan Health System, Ann Arbor, MI;5. Section of Plastic Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI;1. Department of Poultry Production, Faculty of Agriculture, Assiut University, 71526 Assiut, Egypt;2. Departamento de Reproducción Animal, Instituto Nacional de Investigación y Tecnologia Agraria y Alimentaria (INIA), 28040 Madrid, Spain |
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| Abstract: | Contained in this report is a review of available data on pituitary cytokines in domestic species of agricultural importance. The concept is advanced that the pituitary gland is essential to appropriate generation of host defense mechanisms and thus should be considered among other tissues contributing to innate immunity. The functions of these intrapituitary cytokines, principally IL-6, are discussed in the context of potential regulation of the pituitary-adrenal axis (ACTH secretion) via intrapituitary PGE2 generation during the acute-phase response to infectious/inflammatory stimuli. Data from other species are cited as appropriate for comparative purposes and elaboration of proposed mechanisms. However, the scope of the review is not intended to comprehensively cover the vast literature on proinflammatory cytokines and prostaglandins generated peripherally and centrally during host responses to inflammatory stimuli. |
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