Steroidal saponins from Fritillaria pallidiflora Schrenk |
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| Authors: | Shen Shuo Li Guoyu Huang Jian Chen Chaojun Ren Bu Lu Ga Tan Yong Zhang Jiaxu Li Xian Wang Jinhui |
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| Institution: | School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China. |
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| Abstract: | Five new steroidal saponins, Pallidifloside D (1), Pallidifloside E (2), Pallidifloside G (5), Pallidifloside H (6) and Pallidifloside I (7), together with seven other steroidal saponins (3, 4, 8-12) were isolated from the dry bulbs of Fritillaria pallidiflora Schrenk. Their structures were established by spectroscopic techniques (IR, MS, 1D and 2D NMR) and chemical means. The isolated steroidal saponins were evaluated for cyotoxic activity against human C6 brain gliomas and Hela cervix cancer cell lines using MTT assays. Compounds 1, 10, 11, 12 showed cytotoxicity against C6 and Hela cell lines with IC(50) values in the range of 5.1-75.8μM. |
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| Keywords: | Fritillaria pallidiflora Schrenk Steroidal saponins NMR Cytotoxic activity |
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