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Cytotoxic dimeric indole alkaloids from Catharanthus roseus |
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| Authors: | Wang Chun-Hua Wang Guo-Cai Wang Ying Zhang Xiao-Qi Huang Xiao-Jun Zhang Dong-Mei Chen Min-Feng Ye Wen-Cai |
| Affiliation: | Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China. |
| Abstract: | Three new dimeric indole alkaloids (1-3), together with five known ones (4-8), were isolated from the whole plants of Catharanthus roseus. The structures and absolute configurations of new compounds were elucidated by means of NMR and CD analyses. All these compounds were evaluated for their in vitro cytotoxic activities against human breast cancer cell line MDA-MB-231. |
| Keywords: | Catharanthus roseus Apocynaceae Dimeric indole alkaloid Circular dichroism Cytotoxicity |
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