Abyssomicins—A 20-Year Retrospective View |
| |
| Authors: | Hans-Peter Fiedler |
| |
| Institution: | Department of Microbiology/Biotechnology, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tuebingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany; |
| |
| Abstract: | Abyssomicins represent a new family of polycyclic macrolactones. The first described compounds of the abyssomicin family were abyssomicin B, C, atrop-C, and D, produced by the marine actinomycete strain Verrucosispora maris AB-18-032, which was isolated from a sediment collected in the Sea of Japan. Among the described abyssomicins, only abyssomicin C and atrop-abyssomicin C show a high antibiotic activity against Gram-positive bacteria, including multi-resistant and vancomycin-resistant strains. The inhibitory activity is caused by a selective inhibition of the enzyme 4-amino-4-deoxychorismate synthase, which catalyzes the transformation of chorismate to para-aminobenzoic acid, an intermediate in the folic acid pathway. |
| |
| Keywords: | abyssomicins chorismate pathway 4-amino-4-deoxychorismate synthase inhibitor |
|
|
