Chemical Diversity and Biological Activity of Secondary Metabolites from Soft Coral Genus Sinularia since 2013 |
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| Authors: | Xia Yan Jing Liu Xue Leng Han Ouyang |
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| Institution: | 1.Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China; (X.Y.); (J.L.); (X.L.);2.Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China |
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| Abstract: | Sinularia is one of the conspicuous soft coral species widely distributed in the world’s oceans at a depth of about 12 m. Secondary metabolites from the genus Sinularia show great chemical diversity. More than 700 secondary metabolites have been reported to date, including terpenoids, norterpenoids, steroids/steroidal glycosides, and other types. They showed a broad range of potent biological activities. There were detailed reviews on the terpenoids from Sinularia in 2013, and now, it still plays a vital role in the innovation of lead compounds for drug development. The structures, names, and pharmacological activities of compounds isolated from the genus Sinularia from 2013 to March 2021 are summarized in this review. |
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| Keywords: | soft coral Sinularia secondary metabolites bioactivity |
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