| PrP蛋白与Shadoo蛋白研究进展 |
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| 引用本文： | 王东旭,万家余,李忠义,孟珂音,高宏伟.PrP蛋白与Shadoo蛋白研究进展[J].中国畜牧兽医,2011,38(6):215-217. |
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| 作者姓名： | 王东旭 万家余 李忠义 孟珂音 高宏伟 |
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| 作者单位： | 1. 吉林大学畜牧兽医学院,吉林长春 130062;2. 中国人民解放军军事医学科学院军事兽医研究所,吉林长春 130062 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 朊蛋白(PrP蛋白)在传染性海绵状脑病中具有重要作用,但其生物学功能至今没有明确。Shadoo蛋白是一种与朊蛋白在N端结构上极为相似的新蛋白,SPRN是Shadoo蛋白的结构基因。由于Shadoo蛋白与PrP蛋白具有相同的生物学性质,且它们在脑组织中重叠表达,因此也被认为是研究朊蛋白的关键因素。文章主要探讨PrP蛋白与Shadoo蛋白在基因结构、蛋白功能、朊病毒感染方面的关系。
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| 关 键 词： | 朊蛋白 Shadoo蛋白 基因结构 蛋白功能 |
Progress on Prion Protein and Shadoo Protein |
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| WANG Dong-xu,WAN Jia-yu,LI Zhong-yi,MENG Ke-yin,GAO Hong-wei.Progress on Prion Protein and Shadoo Protein[J].China Animal Husbandry & Veterinary Medicine,2011,38(6):215-217. |
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| Authors: | WANG Dong-xu WAN Jia-yu LI Zhong-yi MENG Ke-yin GAO Hong-wei |
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| Institution: | 1. College of Animal Science and Veterinary Medicine, Jilin University,Changchun 130062,China;2. The Military Veterinary Institute,Academy of Military Medical Sciences of PLA,Changchun 130062,China |
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| Abstract: | The prion protein PrP has a key role in transmissible spongiform encephalopathies but its biological function remains largely unknown. Shadoo is a new protein which encoded by the SPRN gene, exhibiting domain organization similar to the N-terminus of PrP. The key factor to study the prion protein is Shadoo because of it’s biological properties and brain distribution partially overlap that of PrP. In this review, we described the relationship between Shadoo protein and PrP proteins in gene structure, protein function and prion infections. |
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| Keywords: | prion protein Shadoo protein gene structure protein function |
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