过量铁和酒精引起大鼠肝损害的病理组织学变化

应用Ｈ．Ｅ．Ｐｅｒｌ＇ｓ，ＶａｎＧｉｅｓｏｎ和ＯｉｌＲｅｄＯ等染色法和光镜观察结果表明：酒精组的肝小叶中央静脉周围肝细胞脂肪变性；铁组的肝细胞和枯否氏细胞含大量铁质颗粒，单个细胞坏死，并出现局灶性炎症；酒精／铁组的小叶中央静脉周围与汇管区周围的肝细胞内积有大量铁质沉着体，结缔组织纤维化，并由汇管区逐渐扩展到小叶中央，呈铁沉着性肉芽肿。

Histopathology of Iron and Alcohol Overload in Rat Liver

The results of serial lingt microscopic studies with H.E.,Perl's, Vangieson and Oil Red O. stainings showed that hepatic parenchyma exhibited some cyto-plasmic vacuolation and fatty change in the pericentral zone in the alcohol group;hepaticparenchymal cells and kuffer cells contained marked concentrations of cytoplasmic gran-ular iron, individual cell necrosis and focal inflammatory changes in the iron group:siderotic bodies were numerous and accumulated in the hepatic cells around the centralveins and portal areas,and the fibrosis of connective tissues appeared and spread gradu-ally from portal area to the pericentral zone in the form of granuloma of siderotic body.