| 动物Toll样受体8的免疫学功能研究进展 |
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| 引用本文： | 刘学良,敖大,姜森. 动物Toll样受体8的免疫学功能研究进展[J]. 动物医学进展, 2022, 43(2): 107-111. DOI: 10.3969/j.issn.1007-5038.2022.02.021 |
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| 作者姓名： | 刘学良 敖大 姜森 |
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| 作者单位： | 扬州大学兽医学院,江苏扬州225009,江苏省动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009,农业与农产品安全国际联合研究实验室,江苏扬州225009 |
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| 基金项目： | 江苏高校优势学科建设工程资助项目;国家自然科学基金 |
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| 摘 要： | Toll样受体是天然免疫中最早发现的模式识别受体,是生物界最古老的免疫系统组成部分之一,在识别病原和影响免疫应答方面具有非常关键的作用。Toll样受体8(TLR8)属于Toll样受体中的TLR7/8/9亚家族,通过识别配体激活信号级联反应,导致促炎细胞因子的产生,发挥抗病毒和抗细菌感染作用。论文就TLR8的结构与活化、配体识别、细胞分布、信号通路、细胞因子产生和疾病相关性等进行简要综述,可使人们更加全面地认识TLR8,对于动物免疫系统的研究以及动物疫病的防控具有一定的参考意义。
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| 关 键 词： | TOLL样受体 信号通路 天然免疫 |
Progress on Immunological Function of Animal Toll-like Receptor 8 |
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| LIU Xue-liang,AO Da,JIANG Sen. Progress on Immunological Function of Animal Toll-like Receptor 8[J]. Progress In Veterinary Medicine, 2022, 43(2): 107-111. DOI: 10.3969/j.issn.1007-5038.2022.02.021 |
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| Authors: | LIU Xue-liang AO Da JIANG Sen |
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| Affiliation: | (College of Veterinary Medicine,Yangzhou University,Yangzhou,Jiangsu,225009,China;Comparative Medicine Research Institute,Yangzhou University,Yangzhou,Jiangsu,225009,China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou,Jiangsu,225009,China;Joint International Research Laboratory of Agriculture and Agri-Product Safety,Yangzhou,Jiangsu,225009,China) |
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| Abstract: | Toll-like receptors(TLRs),the earliest pattern recognition receptors found in innate immunity,are generally considered to be one of the oldest components of the immune system in biology,and play a key role in identifying pathogens and affecting immune response.TLR8 belongs to the TLR7/8/9 subfamily of Toll-like receptors.By recognizing the ligand and activating signal cascades,it leads to the production of pro-inflammatory cytokines and has a corresponding anti-infective effects on viruses and bacteria.This article briefly reviewed the biological functions of TLR8,including structure and activation,ligand recognition,cell distribution,signal pathway,cytokine production and disease correlation.We can make a more comprehensive understanding of TLR8,so that research on the prevention of animal diseases and animal immune system has a certain reference value. |
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| Keywords: | Toll-like receptor singal pathway innate immunity |
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