| 甘氨酸法合成草甘膦中由甲醛引发的副反应研究 |
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| 引用本文： | 黄 明,尹应武,查正炯.甘氨酸法合成草甘膦中由甲醛引发的副反应研究[J].农药学学报,2010,12(1):37-41. |
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| 作者姓名： | 黄 明 尹应武 查正炯 |
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| 作者单位： | 1.西南大学 化学化工学院,重庆 400715 |
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| 摘 要： | 利用核磁共振碳谱、磷谱、氢谱对甘氨酸法合成草甘膦的各阶段反应进行定量跟踪分析, 发现由甲醛引起的副反应是影响草甘膦收率的重要因素之一,证实了羟甲基亚瞵酸、增甘膦、N-甲基草甘膦和亚磷酸是甘氨酸法合成草甘膦的主要副产物,减少或抑制其生成是草甘膦合成工艺优 化的关键。探讨了抑制副反应发生的条件,对甘氨酸法合成草甘膦工艺优化有重要的理论指导意义。
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| 关 键 词： | 草甘膦 机理 副反应 核磁共振 |
| 收稿时间： | 2009/11/11 0:00:00 |
Study of side-reaction on synthesis of glyphosate inducedby glycine method |
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| HUANG Ming,YIN Ying-wu and ZHA Zheng-jiong.Study of side-reaction on synthesis of glyphosate inducedby glycine method[J].Chinese Journal of Pesticide Science,2010,12(1):37-41. |
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| Authors: | HUANG Ming YIN Ying-wu and ZHA Zheng-jiong |
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| Institution: | 1.School of Chemistry and Chemistry Engineering, Southwest University, Chongqing 400715, China2.Department of Chemistry Tsinghua University, Beijing 100084, China3.Th-unis Insight Co. , Ltd. , Beijing 100085, China |
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| Abstract: | It was found that the side-reactions caused by formaldehyde is an important influence factor in the synthesis of glyphosate started from glycine by analysis with 13C NMR,31P NMR,and 1H NMR.Hydroxymethyl phosphonic acid,Polaris,N-(methylation)glyphosate and phosphite were the main by-products and reducing or restraining the generation of them is the crux of optimizing glyphosate technique.Optimizing the technique of synthesizing glyphosate starting from glycine has great significance in theory. |
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| Keywords: | glyphosate mechanism side-reaction NMR |
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