Influence of calcium chloride on the cardio‐respiratory effects of a bolus of enoximone in isoflurane anaesthetized ponies |
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Authors: | Stijn Schauvliege DVM Annelies Van den Eede DVM Luc Duchateau PhD Frederik Pille DVM PhD Diplomate ECVS Lieven Vlaminck DVM PhD Diplomate ECVS Frank Gasthuys DVM PhD Diplomatic ECVAA |
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Institution: | 1. Department of Surgery and Anaesthesia of Domestic Animals, University of Ghent, Merelbeke, Belgium;2. Department of Physiology and Biometrics, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium |
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Abstract: | ObejctiveTo investigate the influence of calcium chloride (CaCl2) on the cardio–respiratory effects of enoximone in isoflurane anaesthetized ponies.Study designProspective consecutive experimental trial.AnimalsSix healthy ponies, weighing 287 ± 55 kg were included in this study.MethodsAfter sedation (romifidine, 80 μg kg?1), anaesthesia was induced with midazolam (0.06 mg kg?1) and ketamine (2.2 mg kg?1) and maintained with isoflurane in oxygen. The ponies’ lungs were ventilated to maintain normocapnia. After 90 minutes, a bolus of enoximone (0.5 mg kg?1) was administered, followed by a CaCl2 infusion (0.5 mg kg?1 minute?1 over 10 minutes) (treatment EC). Sodium, potassium, ionized and total calcium concentrations, cardiovascular variables and blood–gases were measured in the 120 minutes after treatment. Using a mixed model anova, the results were compared to those of a previous report Vet Anaesth Analg, 34 (2007) 416], evaluating the effects of 0.5 mg kg?1 enoximone in the same ponies and under identical circumstances (treatment E). Both an overall comparison and comparisons at specific time points after treatment were performed (α = 0.05).ResultsAlthough ionized and total calcium concentrations were higher during treatment EC, the cardio–respiratory effects of enoximone were comparable for both treatments. A small but significant difference in packed cell volume was detected.Conclusions and clinical relevanceCalcium chloride did not enhance the effects of enoximone in normocalcaemic anaesthetized ponies. |
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Keywords: | calcium chloride enoximone isoflurane pony |
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