| Abstract: | Objective] The paper was clear the effects of ferulic sesquiterpene compounds on enzyme activity of schistosomulum.Method]Mice infected with schistosome cercariae were orally administrated with ferulic sesquiterpene compounds at the dose of 300 mg/kg on the 6 thday post infection once a week for 4 weeks.Schistosomula were collected and ground into homogenate on the 3 rdand 5 thday after every time of administration.Thin layer starch gel electrophoresis was used to observe the activity of enzymes in the homogenate.Control group was also designed(drug free mice).Result] The activities of malic dehydrogenase,6-phophate mannosease and acid phosphatase were obviously inhibited in the drug group,but the activity of phosphoglucoisomerase was not inhibited.Conclusion] Ferulic sesquiterpene compounds have inhibitory effect on energy metabolism of schistosomulum and digestion of red blood cells. |
