Ivermectin in Senegalese Peulh Sheep: Influence of Sex on Plasma Disposition |
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Authors: | T Bengone Ndong Y Kane E H M Diouf M Alvinerie |
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Institution: | (1) Ecole Inter-Etats des Sciences et Médecine Vétérinaires, Dakar Fann, Sénégal;(2) Laboratoire de Pharmacologie–Toxicologie, INRA UR 66, Toulouse, France |
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Abstract: | The plasma disposition kinetics of ivermectin following a single subcutaneous administration of 0.2 mg/kg was investigated
in male and female Senegalese Peulh sheep. Ten clinically healthy animals (5 males and 5 females) weighing 38–45 kg were used
in this trial. Blood samples were collected by jugular puncture at different times between 0.5 h and 30 days post treatment.
After plasma extraction and derivatization, samples were analysed by HPLC with fluorescence detection. Computerized kinetic
analysis was carried out and mean parameters were statistically compared with the Mann–Whitney U-test. The area under the concentration–time curve (AUC) was significantly higher (p < 0.0027) in females than in males. Although the differences in maximum concentration (C
max), mean residence time (MRT) and half-life of elimination (t
1/2el) between males and females did not achieve statistical significance, values tended to be higher in females. Sex differences
may be parallel with the level of storage in fat. Further investigations are required to improve the use of ivermectin in
Senegalese sheep and findings may be used to predict optimal anthelmintic strategies for management of African species depending
on the parasites present in a production system. |
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Keywords: | Senegalese Peulh sheep ivermectin endectocides pharmacokinetics sex influence efficacy |
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