PAIII prostate tumors express prostate specific antigen (PSA) in Lobund-Wistar rats |
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| Authors: | Mark A Suckow James Wheeler and Min Yan |
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| Institution: | 400 Freimann Life Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA (Suckow); Goshen Center for Cancer Care, 200 High Park Ave., Goshen, Indiana 46526, USA (Wheeler, Yan) |
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| Abstract: | Prostate cancer has been modeled in various species, including dogs, mice, and rats. A common method involves the use of transplanted prostate cancer cell lines. The Lobund-Wistar (LW) rat model of prostate cancer allows for the use of models involving either autochthonous prostate cancer or transplantation of a cell line (PAIII), originally derived from a LW rat. The origin of autochthonous prostate tumors in the LW rat is unknown, though suspected to originate from the seminal vesicles. Likewise, the prostatic origin of the PAIII cell line is also uncertain. To determine if the PAIII cell line is derived from the prostate, subcutaneous PAIII tumors from LW rats underwent immunohistochemical labeling for prostate specific antigen (PSA), a prostate-specific serine protease. All 5 PAIII tumors demonstrated labeling for PSA, supporting a prostatic origin for the PAIII cell line. |
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