Nonequilibrium mechanics of active cytoskeletal networks |
| |
Authors: | Mizuno Daisuke Tardin Catherine Schmidt C F Mackintosh F C |
| |
Affiliation: | Department of Physics and Astronomy, Vrije Universiteit, 1081HV Amsterdam, Netherlands. |
| |
Abstract: | Cells both actively generate and sensitively react to forces through their mechanical framework, the cytoskeleton, which is a nonequilibrium composite material including polymers and motor proteins. We measured the dynamics and mechanical properties of a simple three-component model system consisting of myosin II, actin filaments, and cross-linkers. In this system, stresses arising from motor activity controlled the cytoskeletal network mechanics, increasing stiffness by a factor of nearly 100 and qualitatively changing the viscoelastic response of the network in an adenosine triphosphate-dependent manner. We present a quantitative theoretical model connecting the large-scale properties of this active gel to molecular force generation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|