| 蛇葡萄素对家兔离体子宫平滑肌收缩性能的影响 |
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| 引用本文： | 朱慧玲,胡春菊,黄先菊,张昊.蛇葡萄素对家兔离体子宫平滑肌收缩性能的影响[J].长江大学学报,2005,2(12):352-354. |
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| 作者姓名： | 朱慧玲 胡春菊 黄先菊 张昊 |
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| 作者单位： | 长江大学,医学院,湖北,荆州,434000;韩山师范学院,广东,潮州,521041 |
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| 摘 要： | 目的:探讨蛇葡萄素(Ampeloptin,AP)对多种物质诱导的子宫平滑肌收缩的抑制作用.方法:离体子宫平滑肌实验方法.结果:AP能够显著抑制子宫平滑肌自律性及氯化钾、缩宫素诱导的家兔离体子宫平滑肌收缩反应.AP对高K 除极化后Ca2 诱导的子宫平滑肌收缩有松弛作用.AP对缩宫素所致子宫的依内钙收缩及CaCl2引起的依外钙收缩均有明显抑制作用,且对前者抑制作用更为明显.结论:AP对家兔离体子宫平滑肌有较好的松弛作用.
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| 关 键 词： | 平滑肌 子宫 蛇葡萄素 缩宫素 氯化钾 氯化钙 维拉帕米 |
| 文章编号： | 1673-1409(2005)12-0352-03 |
| 修稿时间： | 2005年9月28日 |
Effect of Ampelopsin on the Contraction of Isolated Uterus of Rabbits Induced by Some Mediators |
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| ZHU Hui-ling,HU Chun-ju,HUANG Xian-ju,ZHAO Hao.Effect of Ampelopsin on the Contraction of Isolated Uterus of Rabbits Induced by Some Mediators[J].Journal of Yangtze University,2005,2(12):352-354. |
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| Authors: | ZHU Hui-ling HU Chun-ju HUANG Xian-ju ZHAO Hao |
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| Abstract: | Objective:To observe the antagonism of Ampelopsin(AP) on the contraction of isolated uterus of rabbits induced by some mediators.Methods:In vitro experimental method of smooth muscle was used.Results:AP and Ver can inhibit the contractile rhythms of uterus and contraction of isolated uterus of rabbits induced by KCL and oxytocin.AP can inhibit the contraction of isolated uterus induced by Ca~(2+) after the uterus was depolarized by high concentration of K~+.And it can also inhibit intracellular Ca~(2+)-dependent contraction induced by oxytocin and extra cellular Ca~(2+)-dependent contraction induced by CaCl_2 respectively,especially the former one.Conclusion:AP has significant relaxing effect on the contraction of isolated uterus. |
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| Keywords: | Smooth muscle Uterus Ampelopsin Oxytocin KCl CaCl_2 Verapamil |
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