二氟沙星对实验性感染猪链球菌病及支原体性肺炎的药效学研究

本文报道国内新近研制的畜禽专用氟喹诺酮类抗菌药物－二氟沙星对实验性感染猪链球菌病及支原体性肺炎的药效学研究。以试管两倍稀释法测得二氟沙星对兰氏C群类马链球菌（C55120）和猪肺炎支原体（F16株）的最小抑菌浓度（MIC）分别是1．6级及0．16mg/L。肌注给药对猪链球菌病和支原体性肺炎的实验性治疗结果表明，低、中、高剂量二氟沙星组（2．5、5、10mg/kg)及恩诺沙星组（2．5mg/kg)用药5d（每隔12h给药1次）对猪链球菌病的治愈分别是40％、70％、80％及70％，而链球菌感染对照组的死亡率为70％；低、中、高剂量二氟沙星组及恩诺沙星组（2．5mg/kg)用药5d（每隔12h给药1次）对猪支原体性肺炎的治愈率分别是80％、90％、90％及80％；而支原体感染对照组的自愈率为10％。

PHARMACOKINETIC STUDIES OF DIFLOXACIN AGAINST EXPERIMENTALLY INDUCED STREPTOCOCCOSIS AND MYCOPLASMAL PNEUMONIA IN PIGS

This paper described the pharmacodynamic studies of difloxacin and enrofloxacin against experimentally induced streptococcosis and mycoplasmal pneumonia in pigs.Minimal inhibitory concentrations(MICs) of the two drugs were determined for Streptococcus equisilis or Mycoplasma hyopneumoniae by twofold dilution method in vitro .The therapeutic trials of difloxacin (25,5 and 10 mg/kg) and enrofloxacin (25 mg/kg)against experimentally induced streptococcosis were carried out in pigs following intramuscular administration,twice daily for 5 successive days.The therapeutic trials of difloxacin (25,5 and 10 mg/kg) and enrofloxacin(25 mg/kg) against artificially induced mycoplasmal pneumonia were performed in pigs following intramuscular administration,twice daily for 5 successive days.MICs of difloxacin and enrofloxacin were 16 and 08 mg/L for Streptococcus equisimilis ,respectively.MICs of difloxacin and enrofloxacin were 016 and 004 mg/L for Mycoplasma hyopneumoniae ,respectively.Following the treatment with difloxacin(25,5 and 10 mg/kg) and enrofloxacin (25 mg/kg)against streptococcosis for 5 days,the cure rates of the infected pigs were 40%,70%,80% and 70%,respectively.The mortality of the infected and untreated group was 70%.Following the treatment with difloxacin(25,5 and 10 mg/kg) and enrofloxacin(25 mg/kg) against mycoplasmal pneumonia for 5 days,the cure rates of the infected pigs were 80%,90%,90%,and 80%,respectively.The selfcure rate of the infected and untreated group was 10%.