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Characterisation of the in vivo interactions between detomidine and methadone in horses: Pharmacokinetic and pharmacodynamic modelling
Authors:M. Gozalo-Marcilla  S. P. L. Luna  R. Moreira da Silva  N. Crosignani  N. P. Lopes  P. M. Taylor  L. Pelligand
Affiliation:1. Department of Veterinary Surgery and Anaesthesiology, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil;2. Núcleo de Pesquisas em Produtos Naturais e Sintéticos (NPPNS), School of Pharmaceutical Sciences, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil;3. Taylor Monroe, Ely, Cambridgeshire, UK;4. Department of Clinical Services and Sciences and Comparative Biomedical Sciences, Royal Veterinary College, Hatfield, Hertfordshire, UK
Abstract:
Keywords:horse  opioid  alpha 2 agonist  synergism  sedation  nociceptive threshold
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