弓形虫强毒株人工接种仔猪淋巴器官的动态病理形态学

以弓形虫强毒株静脉接种2—3月龄仔猪的结果表明,仔猪感染弓形虫强毒株后,淋巴结的动态病理过程表现为单纯性、坏死性和增生性淋巴结炎的变化规律,并可见肺门淋巴结损伤较其他淋巴器官为重。在疾病经过的严重期,淋巴结、脾、胸腺和骨髓的淋巴细胞数量均显著减少,同时,淋巴细胞的超微结构发生由胞膜突起、凹陷和断裂到染色质的聚集、崩解等不同程度的质的改变。从免疫形态学上表明,在恢复期病例,体内出现了体液免疫和细胞免疫。文中还详细描述了巨噬细胞与虫体的相互作用在不同阶段细胞超微结构变化特点,以及巨噬细胞、浆细胞、嗜酸性粒细胞和淋巴细胞等免疫活性细胞的消长规律。

OBSERVATIONS ON THE DYNAMIC PATHOMORPHOLOGICAL CHANGES OF LYMPHATIC ORGANS IN PIGS INFECTED EXPERIMENTALLY WITH TOXOPLASMA

A study was made of dynamic process of changes of histopathology andultrastr uctural pathology of lymphatic organs in pigs,2—3 months old,infectedintravenously high virulente strain of toxoplasma.Affected pigs were killedand examined at intervals up to 15 days.Observations were made on the lymphnodes,spleen,thymus and bone morrow by the methods of optical and electronmicroscopy.The results indicated that lymph nodes showed varing changes withearly simple lymphadenitis and later necrotic and productive lymphadeni-tis more than a simple necrosis,and that a marked lymphocyte depletion wasseen in the lymph nodes,spleen,thymus and bone morrow during the mediateor late periods.In addition,a fully hyperplasia of lymphocyte and numerousplasma cells of these lymphatic organs in the convalescing cases were indicativeto the humoral immune and cell mediate response,and the toxoplasma proli-feration was found in the cytoplasm of macrophages under the electron micro-scopy.We also discribed in detail the changes in ultrastr uctures and numbersof lymphocytes and macrophages in different stages.These findings mayhelp to elucidate the pathogenesis of toxoplasmosis of pig and the nature ofthe complex immune response.