Polymorphism Analysis of Microsatellites Associated with Seven Candidate Genes for Equine Cryptorchidism |
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| Authors: | Mathieu Diribarne,Anne Vaiman,Michel Pé chayre,E. Pailhoux,Xavier Mata,Gé rard Gué rin,Sté phane Chaffaux |
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| Affiliation: | 1. INRA, CRJ, UR 339 Laboratoire de Génétique biochimique et Cytogénétique, 78350 Jouy-en-Josas, France;2. Clinique vétérinaire des Aigles, Lamorlaye, France;3. INRA, CRJ, UMR 1198 Biologie du Développement et Reproduction, 78350 Jouy-en-Josas, France |
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| Abstract: | Association of seven candidate genes with cryptorchidism was investigated in the Thoroughbred. A pedigree composed of 23 cryptorchids and 24 nonaffected horses, sharing a common ancestor, was constituted. Sixteen microsatellite markers were developed either from bacterial artificial chromosomes (BAC) isolated for each candidate gene or by in silico screening. DNA from our pedigree was genotyped for these microsatellites. Statistical analysis of the allelic and genotypic frequencies observed with these markers did not reveal any association between the candidate genes and the cryptorchidism phenotype in our horse panel. |
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| Keywords: | Cryptorchidism Thoroughbred Candidate genes Microsatellite Association analysis |
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