安氟醚麻醉时母羊、胎儿血药浓度及呼气浓度的研究

本文应用气相色谱平衡法测定了妊娠绵羊安氟醚吸入麻醉期间母羊,胎儿血药浓度和终末呼吸气浓度。该法具有精度高、出峰快、重复性能好等优点(其中气样r=0.9998,p<0.001;血样r=0.998,P<0.001)。结果表明:母羊和胎儿血药浓度时间曲线显著相关(上升相r=0,9443,p<0.05;消除相r=0.999,p<0.001)。药物代谢动力学(以下简称药代动力学)计算表明:安氟醚在绵羊体内血药浓度时间规律为:C=12.48329(e~(-0.0344964t)-e~(-0.03262423t))血药浓度峰值时间Tm=9.112分,峰浓度Cm=8.47699mg/100ml。血药浓度同理论值(回归值)极为相似,无统计学显著性差异(p>0.05).

STUDIES ON MATERNAL AND FETAL ANESTHRTIC CONCENTRATONS IN BLOOD AND RESPTRATORY GASES DURING ENFLURANE ANESTHESIA OF PREGNANT SHEEP

This thesis deals with the maternal and fetal blood and expiratory air enflurane concentrations which was deterimined by the gas chromatography during enlurane inhalation anesthesia of 8 pregnant sheep. It has the features of high precision, quick, good repeatability gas sample:r=0.9998 p<0.001, blood sample: r=0.998 p<0.001). The results indicate that the relationship of the time curve between maternal and fetal blood anesthetic concentrations was significant (ascending phase: y=0.9259x-1.33 r=0.9443 p<0.05; eliminating phase: y=0.9655x-1.383, r=0.999, p<0.001). According to the pharmacokinetic analysis, the concentration-time law of the anesthetic is C=12.48329(e~(-0.034469t)-e~(-0.03262423t)), T_m=9.118min, C_m=8.47699 mg/100ml. The blood anesthetic concentration is exactly approximate to the theoretical value (the regression value) (p>0.05).