Genetics of equine bleeding disorders |
| |
Authors: | Anna R. Dahlgren Fern Tablin Carrie J. Finno |
| |
Affiliation: | 1. Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, USA;2. Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA, USA |
| |
Abstract: | Genetic bleeding disorders can have a profound impact on a horse's health and athletic career. As such, it is important to understand the mechanisms of these diseases and how they are diagnosed. These diseases include haemophilia A, von Willebrand disease, prekallikrein deficiency, Glanzmann's Thrombasthenia and Atypical Equine Thrombasthenia. Exercise-induced pulmonary haemorrhage also has a proposed genetic component. Genetic mutations have been identified for haemophilia A and Glanzmann's Thrombasthenia in the horse. Mutations are known for von Willebrand disease and prekallikrein deficiency in other species. In the absence of genetic tests, bleeding disorders are typically diagnosed by measuring platelet function, von Willebrand factor, and other coagulation protein levels and activities. For autosomal recessive diseases, genetic testing can prevent the breeding of two carriers. |
| |
Keywords: | horse haemophilia A von Willebrand disease prekallikrein deficiency Glanzmann's thrombasthenia atypical equine thrombasthenia |
|
|