New Briarane diterpenoids from the gorgonian coral Junceella juncea |
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| Authors: | Jiun-Yang Chang Chia-Ching Liaw Ahmed Eid Fazary Tsong-Long Hwang Ya-Ching Shen |
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| Affiliation: | School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd Sec 1, Taipei 101-200, Taiwan. nomatter2200@hotmail.com |
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| Abstract: | Chemical investigation of Junceella juncea has resulted in the isolation of three new briaranes designated juncenolides M-O (1-3). The structures of these compounds were determined by spectroscopic analysis including 2D-NMR (COSY, HMBC and NOESY) and HRMS. Compound 1 is a new chlorinated briarane while compound 3 contains a rare methyl ester at C-16. The anti-inflammatory activities tested on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB were evaluated. |
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| Keywords: | Junceella juncea briaranes anti-inflammatory activity |
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