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Marine cyclotripeptide X-13 promotes angiogenesis in zebrafish and human endothelial cells via PI3K/Akt/eNOS signaling pathways |
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| Authors: | Xi-Lin Lu Zhong-Liang Xu Xiao-Li Yao Feng-Juan Su Cheng-Hui Ye Jing Li Yong-Cheng Lin Guang-Lei Wang Jin-Sheng Zeng Ru-Xun Huang Jing-Song Ou Hong-Shuo Sun Li-Ping Wang Ji-Yan Pang Zhong Pei |
| Institution: | Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. luxilin@mail.sysu.edu.cn |
| Abstract: | Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and Akt and NO release. Inhibition of PI3K/Akt/eNOS by LY294002 or L-NAME suppressed X-13-induced angiogenesis. The present work demonstrates that X-13 promotes angiogenesis via PI3K/Akt/eNOS pathways. |
| Keywords: | angiogenesis marine cyclotripeptide zebrafish endothelial nitric oxide synthase xyloallenoide A |
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