Simplexins P-S, eunicellin-based diterpenes from the soft coral Klyxum simplex |
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| Authors: | Shwu-Li Wu Jui-Hsin Su Chiung-Yao Huang Chi-Jen Tai Ping-Jyun Sung Chih-Chung Liaw Jyh-Horng Sheu |
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| Affiliation: | Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wusl@webmail.nkmu.edu.tw |
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| Abstract: | Four new eunicellin-based diterpenes, simplexins P-S (1-4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3-5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic. |
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| Keywords: | soft coral eunicellin-based diterpenes cytotoxicity Klyxum simplex |
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