| 麻保沙星在中国对虾体内药代动力学及残留研究 |
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| 引用本文： | 张海珍,李健,王群,刘淇,周一兵.麻保沙星在中国对虾体内药代动力学及残留研究[J].中国农业科技导报,2008,10(2):88-93. |
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| 作者姓名： | 张海珍 李健 王群 刘淇 周一兵 |
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| 作者单位： | [1]大连水产学院生命科学与技术学院,辽宁大连116023 [2]中国水产科学研究院黄海水产研究所,农业部海洋渔业资源可持续利用重点开放实验室,山东青岛266071 |
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| 基金项目： | 国家科技支撑计划
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公益性农业行业科研专项
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科技部社会公益研究项目 |
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| 摘 要： | 高效液相色谱法测定水温20±1℃条件下，2．5mg·kg^-1剂量肌注和口服麻保沙星在中国对虾体内的药代动力学及残留规律。采用3p97药动学软件处理数据，结果表明：肌注给药的药时数据符合一级吸收二室、开放模型，主要药动学参数如下：血淋巴、肌肉、肝胰腺内的Tmax和Cmax分别为0．147h．0．039h．0．103h和3．688μg·mL^-1、2．7331μg·mL^-1、4．524μg·mL^-1，AUC分别为8．474μg·mL^-1·h^-1、2．396μg·mL^-1·h^-1、18．310μg·mL^-1·h^-1（1／2）。为0．893h,0．103h、1．257h；t（1／2）B为9．866h、2．648h,4．947h，CL为0．118L·h^-1·kg^-1、1．043L·h^-1·kg^-1、0．137L·h^-1·k^-1。连续口服给药三种组织中消除半衰期分别为8．74h,55．14h．5．72h。根据本试验结果及多剂量给药原则，麻保沙星的合理给药方案为：口服2．5mg·kg^-1的剂量，每日1次给药。
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| 关 键 词： | 中国对虾 麻保沙星 药动学 残留 |
| 收稿时间： | 2008-02-28 |
| 修稿时间： | 2008-03-05 |
Studies on Pharmacokinetics and Residues of |Marbofloxacin in Penaeus chinensis |
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| ZHANG Hai-zhen,LI Jian,WANG Qua,LIU Qi,ZHOU Yi-bing.Studies on Pharmacokinetics and Residues of |Marbofloxacin in Penaeus chinensis[J].Journal of Agricultural Science and Technology,2008,10(2):88-93. |
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| Authors: | ZHANG Hai-zhen LI Jian WANG Qua LIU Qi ZHOU Yi-bing |
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| Institution: | 1. College of Life Sciences and Biotechnology, Dalian Fisheries University, Liaoning Dalian 116023 ; |2. Key 0pen Laboratory of Ministry of Agriculture for Sustainable Utilization of Marine FiShery Resources, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shandong Qingdao,266071, China |
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| Abstract: | This paper reports pharmacokinetics and residues of marbofloxacin in Fenneropenaeus chinensis at 20 ± 1℃. Hemolymph、muscle and hepatopancreas were sampled after intrmuscular administration and repeat oral administration at a dose of 2.5mg·kg^- 1 body weight. The concentration of medicament in tisssues was determined by HPLC. The data were analyzed with the pharmacokinetics computer program 3p97. The concentration-time course of marbofloxacin in the tissues could be described by a two-compartment open model. The main pharmacokinetics parameters in hemo- lymph,muscle and hepatopancreas were as follows： Tmax 0. 147 h,0.039 h,0. 103 h; Cmax 3.688μg·mL^-1、2.731μg·mL^-1、4.524μg·mL^-1,AUC 8.474μg·mL^-1·h^-1、2.396μg·mL^-1·h^-1、18.3100μg·mL^-1·h^-1（1/2）.0.893h,0.103h、1.257h;t（1/2）B 9.866h、2.648h,4.947h,CL 0.118L·h^-1·kg^-1、1.043L·h^-1·kg^-1、0.137L·h^-1·k^-1 After repeat oral administration, t（1/2）~were 8.74 h,5.14 h,5.72 h. Base on the data above, we suggested Fenneropenaeus chinensis could take marbofloxacin once per day by oral administration （2.5mg · kg^-1）. |
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| Keywords: | Fenneropenaeus chinensis marbofloxaein pharmaeokineties residues |
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