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槲皮素单硫酸酯钠盐和柚皮素单硫酸酯钠盐对小鼠出血时间和凝血时间的影响
引用本文:周毅,杨夏敏,黄智艺,郑允,陈汉华,罗燕媚,刘文. 槲皮素单硫酸酯钠盐和柚皮素单硫酸酯钠盐对小鼠出血时间和凝血时间的影响[J]. 湛江医学院学报, 2011, 29(5): 477-478
作者姓名:周毅  杨夏敏  黄智艺  郑允  陈汉华  罗燕媚  刘文
作者单位:周毅 (广东医学院第一临床医学院,广东湛江,524023) ; 杨夏敏 (广东医学院第一临床医学院,广东湛江,524023) ; 黄智艺 (广东医学院第一临床医学院,广东湛江,524023) ; 郑允 (广东医学院第一临床医学院,广东湛江,524023) ; 陈汉华 (广东医学院第一临床医学院,广东湛江,524023) ; 罗燕媚 (广东医学院第一临床医学院,广东湛江,524023) ; 刘文 (广东医学院生物化学与分子生物学研究所,广东湛江,524023) ;
基金项目:,广东省重点学科基金,广东省大学生创新实验项目基金
摘    要:目的 了解槲皮素单硫酸酯钠盐(SQMS)和柚皮素单硫酸酯钠盐(SNMS)对小鼠出血时间(BT)和凝血时间(CT)的影响.方法80只昆明小鼠随机分成8组,即生理盐水组(阴性对照),低、中、高剂量SQMS和SNMS组,血栓通组(阳性对照),每组10只.BT及CT分别采用断尾法和玻片法观察.结果 SQMS和SNMS名-剂量组...

关 键 词:槲皮素  柚皮素  出血时间  凝血时间

Effects of sodium quercetin monosulfate salt and sodium naringenin monosulfate salt on bleeding and clotting time in mice
ZHOU Yi,YANG Xia-min,HUANG Zhi-yi,ZHENG Yun,CHEN Han-hua,LUO Yan-mei,LIU Wen. Effects of sodium quercetin monosulfate salt and sodium naringenin monosulfate salt on bleeding and clotting time in mice[J]. Journal of Guangdong Medical College, 2011, 29(5): 477-478
Authors:ZHOU Yi  YANG Xia-min  HUANG Zhi-yi  ZHENG Yun  CHEN Han-hua  LUO Yan-mei  LIU Wen
Affiliation:1. The First Clinical Medical School, Guangdong Medical College, Zhanjiang 514023, China)
Abstract:Objective To study the effects of sodium quercetin .monosulfate salt (SQMS) and sodium naringenin monosulfate salt (SNMS) on bleeding time (BT) and clotting time (CT) in mice. Methods Eighty Kunming mice were randomly divided into eight groups including normal saline group, three-dose SQMS and SNMS groups, and Xueshuantong group, each of 10 animals. BT and CT were measured by tail-cutting and slice methods, respectively. Results BT and CT in SQMS and SNMS groups were longer than those in normal saline group (P〈0.05). The anticoagulant effect of SQMS and SNMS was similar to that of Xueshuantong injection (P〉0.05), but CT in high-dose SNI~IS group was superior to that in Xueshuantong group (P〈0.05). Conclusion Both SQMS and SNMS are anticoagulant.
Keywords:quercetin  naringenin  bleeding time  clotting time
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