Tannins from barks of Pinus caribaea protect Escherichia coli cells against DNA damage induced by gamma-rays |
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Authors: | Fuentes J L Vernhe M Cuetara E B Sánchez-Lamar A Santana J L Llagostera M |
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Affiliation: | Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear (CEADEN), Miramar, Playa, Ciudad de la Habana, Cuba. jlfuentes2005@yahoo.es |
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Abstract: | This work was aimed to evaluate genotoxicity and antigenotoxicity activity against gamma-rays of a tannin fraction obtained from barks of Pinus caribaea, as well as to elucidate the antigenotoxic mechanisms involved in radioprotection by using different approaches as pre-, co- and post-irradiation cell treatments with plant extract. The tannin fraction was not genotoxic to Escherichia coli cells in experiments using different exposure times. This extract was antigenotoxic against gamma-rays when the cells were pre- or co-treated with this extracts, but not during post-irradiation treatments, suggesting a possibly antigenotoxic action through free radical scavenging mechanisms. The results are discussed in relation to the chemopreventive and therapeutic potential of the studied plant species. |
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Keywords: | Pinus caribaea Escherichia coli Tannins SOS chromotest-radioprotectors |
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